Hydrochloric Acid → HCID 24750645, compound

Participants

Reaction Steps

Ethyl 5-bromo-2-({[(3-methylphenyl)sulfonyl]carbamoyl}amino)-1,3-thiazole-4-carboxylate (50 mg, 0.11 mmol) was treated with sodium borohydride (21 mg, 0.56 mmol) in tetrahydrofuran (2 ml) for 2 days at room temp. 0.5 M HCl was added and the quenched reaction mixture was purified on preparative HPLC yielding 21 mg of the title compound as an amorphous solid. MS (ES): m/e 404.1 (M−H)

Provenance & Evidence