Pyridine → 2(R)-acetoxycyclopent-1(R)-yl chloroformate

Participants

Role	Name	HCID	Charge
Reactant	Pyridine	HCID 1049	—
Reactant	Triphosgene	HCID 94429	—
Reactant	(1R,2R)-2-Hydroxycyclopentyl acetate	HCID 12483669	—
Solvent	Dichloromethane	HCID 6344	—
Product	2(R)-acetoxycyclopent-1(R)-yl chloroformate	HCID 86590563	—

Reaction Conditions

Temperature	0 °C

Reaction Steps

To a stirred solution of (1R,2R)-trans-2-acetoxy-1-cyclopentanol (1.0 g, 6.9 mmol) in dichloromethane (25 mL) at 0° C. under nitrogen atmosphere was added pyridine (0.88 mL, 10.4 mmol) followed by a solution of triphosgene (1.03 g, 3.5 mmol) in dichloromethane (25 mL). The reaction mixture was stirred at 0° C. for 30 min. to provide the corresponding 2(R)-acetoxycyclopent-1(R)-yl chloroformate which was carried to next step without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07868041B2
Source dataset	uspto-grants-2011_01
ORD ID	ord-93106a263f1f47889731f54e49d9bdcb
Source note	uspto-grants-2011_01