Pyridinium chloride → 5-[2-(2,4-Difluorophenyl)ethenyl]-2-1-propyl-1,3-benzenediol

HRID 252335Notes

Reaction equation

HRID 252335 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]1[CH:16]=[C:15]([O:17]C)[C:14]([CH2:19][CH2:20][CH3:21])=[C:13]([O:22]C)[CH:12]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[CH:10][C:11]1[CH:12]=[C:13]([OH:22])[C:14]([CH2:19][CH2:20][CH3:21])=[C:15]([OH:17])[CH:16]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 668427441-(2,4-Difluorophenyl)-2-(3,5-d-imethoxy-4-1-propylphenyl)ethene

Product 1

HCID 668429515-[2-(2,4-Difluorophenyl)ethenyl]-2-1-propyl-1,3-benzenediolYield 44%

Procedure

This material was prepared from 1-(2,4-difluorophenyl)-2-(3,5-dimethoxy-4-1-propylphenyl)ethene and pyridine hydrochloride in 44% yield in the same way as described in Example 34. 1HNMR (CDCl3, ppm): δ 1.41 (d, J=7.1 Hz, 6H), 3.49 (qint, J=7.1 Hz, 1H), 4.78 (br, 2H), 6.54 (s, 2H), 6.69-7.02 (m, 3H), 7.13 (d, J=16 Hz, 1H), 7.41-7.75 (m, 1H).

Sources & evidence

ORD record
ord-8bffcb100de946eb8a129ea6a7989928
Source dataset
uspto-grants-2011_01
Patent number
US07868047B2

Reaction notes

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