反应详情

温度

45 °C

A mixture of 21 mmol 5-bromo-3-(3-methoxy-propoxy)-1H-pyridin-2-one, 14 mmol silver carbonate and 25 mmol iodomethane in 35 ml of benzene are stirred at 40-50° C. for 24 hours with exclusion of light. The mixture is cooled in an ice bath and the silver salts are removed by filtration. The filtrate is washed with 2% aqueous sodium hydrogencarbonate solution and with water (2×). The organic layer is dried over sodium sulphate, filtered and concentrated. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F) and identified based on its Rf value.

1. temperatureThe mixture is cooled in an ice bath
2. customthe silver salts are removed by filtration
3. washThe filtrate is washed with 2% aqueous sodium hydrogencarbonate solution and with water (2×)
4. dry with materialThe organic layer is dried over sodium sulphate
5. filtrationfiltered
6. concentrationconcentrated