HCID 178418634, compound → HCID 178500374, compound

HRID 252382Notes

Reaction equation

HRID 252382 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]([C@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]=[N+]=[N-])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[C:17]([OH:20])(=S)[CH3:18]>>[CH3:1][O:2][C:3](=[O:16])[C:4]([C@H:7]1[CH2:12][CH2:11][C@H:10]([NH:13][C:17](=[O:20])[CH3:18])[CH2:9][CH2:8]1)([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 178418634HCID 178418634, compoundHCID 178500375HCID 178500375, compound

Product 1

HCID 178500374HCID 178500374, compound

Procedure

A round bottom flask is charged with 0.422 g of trans-2-(4-azido-cyclohexyl)-2-methyl-propionic acid methyl ester. 0.71 ml of thioacetic acid are added and the solution is stirred for 1 hour at room temperature. After completion of the reaction, the reaction mixture is concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction mixture is concentrated by evaporation

Sources & evidence

ORD record
ord-f6baf08ee4d24cc89cfe4934973853ba
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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