反应详情

0.992 g of 2-methyl-2-piperidin-3-yl-propionic acid methyl ester hydrochloride are dissolved in 2.2 ml of 2M NaOH. The solution is stirred for 10 minutes at room temperature. 7 ml of formic acid and 0.900 ml of 36% aqueous formaldehyde solution are added and the mixture is warmed to 60° C. for 16 hours. The solution is concentrated under reduced pressure. The residue is taken up water and the pH adjusted to 8-9 with saturated sodium carbonate solution. The mixture is extracted with ethyl acetate (3×) and tetrahydrofuran (2×)—the combined extracts are dried over sodium sulphate and concentrated. The title compound is obtained as a yellow oil from the residue by means of flash chromatography (SiO2 60F). Rf=0.23 (200:20:1 dichloromethane/methanol/25% conc. ammonia).

1. temperaturethe mixture is warmed to 60° C. for 16 hours
2. concentrationThe solution is concentrated under reduced pressure
3. extractionThe mixture is extracted with ethyl acetate (3×) and tetrahydrofuran (2×)—the combined extracts
4. dry with materialare dried over sodium sulphate
5. concentrationconcentrated