Sodium Hydroxide → HCID 178484016, compound
Reaction equation
C[O:2][C:3](=[O:16])[C:4]([C@H:7]1[CH2:12][CH2:11][C@@H:10]([N:13]([CH3:15])[CH3:14])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[OH-].[Na+]>CO>[CH3:15][N:13]([CH3:14])[C@@H:10]1[CH2:9][CH2:8][C@H:7]([C:4]([CH3:5])([CH3:6])[C:3]([OH:16])=[O:2])[CH2:12][CH2:11]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
0.500 g of cis-(4-dimethylamino-cyclohexyl)-methyl-propionic acid methyl ester are taken up in 5 ml of methanol and the mixture is admixed with 5 ml of 3M NaOH. The mixture is then stirred at 60° C. for 16 hours. The methanol is removed in vacuo and the aqueous residue acidified with 2M HCl to pH 7. The mixture is concentrated under reduced pressure. The residue is taken up in 10 ml of ethanol and the insoluble salts removed by filtration. Concentration of the filtrate under reduced pressure provides the title compound which can be used without further purification.
Workup
- customThe methanol is removed in vacuo
- concentrationThe mixture is concentrated under reduced pressure
- customthe insoluble salts removed by filtration
Sources & evidence
- ORD record
- ord-9ea03af5e33246e39da86e9556ef43a1
- Source dataset
- uspto-grants-2011_01
- Patent number
- US07868036B2
Reaction notes
Loading…