Sodium Hydroxide → HCID 66887403, compound

HRID 252393Notes

Reaction equation

HRID 252393 reaction equation
C([O:3][C:4](=[O:14])[C:5]([CH3:13])([C:7]1[N:8]=[CH:9][N:10]([CH3:12])[CH:11]=1)[CH3:6])C.[OH-].[Na+]>CO>[CH3:13][C:5]([C:7]1[N:8]=[CH:9][N:10]([CH3:12])[CH:11]=1)([CH3:6])[C:4]([OH:14])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66887984HCID 66887984, compound

Product 1

HCID 66887403HCID 66887403, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

1.96 g of 2-methyl-2-(1-methyl-1H-imidazol-4-yl)-propionic acid ethyl ester is taken up in 10 ml of methanol and the mixture is admixed with 10 ml of 3M NaOH. The mixture is then stirred at 60° C. for 16 hours. The methanol is removed in vacuo and the aqueous residue acidified with 2M HCl to pH 7. The mixture is concentrated under reduced pressure. The residue is taken up in 10 ml of ethanol and the insoluble salts removed by filtration. Concentration of the filtrate under reduced pressure provides the title compound which can be used without further purification.

Workup

  1. customThe methanol is removed in vacuo
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customthe insoluble salts removed by filtration

Sources & evidence

ORD record
ord-45e207c4994a41f0826dc3c3e320ae51
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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