N-(4-fluoro-thiobenzoyl)acetamide → HCID 178475090, compound

HRID 25240Notes

Reaction equation

HRID 25240 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][C:9](=[O:11])[CH3:10])=S)=[CH:4][CH:3]=1.Cl.Cl.[NH2:16][CH:17]([CH2:30][CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[C:18]([NH:20][C:21]1([C:28]#[N:29])[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1)=[O:19]>>[C:9]([N:8]=[C:6]([NH:16][CH:17]([CH2:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1)[C:18]([NH:20][C:21]1([C:28]#[N:29])[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1)=[O:19])[C:5]1[CH:12]=[CH:13][C:2]([F:1])=[CH:3][CH:4]=1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 22063421N-(4-fluoro-thiobenzoyl)acetamideHCID 225663392-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt

Product 1

HCID 178475090HCID 178475090, compound

Procedure

The title compound was prepared starting from N-(4-fluoro-thiobenzoyl) acetamide and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 1, step b. MS, m/z 456=M+1.

Sources & evidence

ORD record
ord-b87e5d5ea70541d8af6614899ae37e02
Source dataset
uspto-grants-2005_02
Patent number
US06858623B2

Reaction notes

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