HCID 86618889, compound → HCID 86618888, compound

HRID 252420Notes

Reaction equation

HRID 252420 reaction equation
[N:1]([CH2:4][CH:5]([CH:7]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:8][CH:9]([CH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[N:19]([CH3:23])[CH:18]=[C:17]2[CH2:24][CH2:25][CH2:26][O:27][CH3:28])[CH:10]([CH3:12])[CH3:11])[OH:6])=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH:5]([CH:7]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:33])([CH3:35])[CH3:34])[CH2:8][CH:9]([CH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[N:19]([CH3:23])[CH:18]=[C:17]2[CH2:24][CH2:25][CH2:26][O:27][CH3:28])[CH:10]([CH3:11])[CH3:12])[OH:6]

Participants

4

Reactant 1

HCID 86618889HCID 86618889, compound

Product 1

HCID 86618888HCID 86618888, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The solution of 0.51 g of tert-butyl {1-(2-azido-1-hydroxyethyl)-3-[3-(3-methoxypropyl)-1-methyl-1H-indol-5-ylmethyl]-4-methylpentyl}carbamate in 15 ml of methanol is hydrogenated in the presence of 0.11 g of 10% Pd/C over 1 hour. The reaction mixture is clarified by filtration and concentrated by evaporation. The title compound is identified on the basis of the Rf value from the residue.

Workup

  1. filtrationThe reaction mixture is clarified by filtration
  2. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-0a16c910f9be45b2bb45cf82448d5b5e
Source dataset
uspto-grants-2011_01
Patent number
US07868036B2

Reaction notes

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