Ammonium Chloride → HCID 86618889, compound

Participants

Reaction Steps

The solution of 0.59 g of tert-butyl {3-[3-(3-methoxypropyl)-1-methyl-1H-indol-5-ylmethyl]-4-methyl-1-oxiranylpentyl}carbamate (Example 3Ab) in 12 ml of methanol is admixed with 0.21 g of sodium azide and 0.12 g of ammonium chloride and stirred at reflux over 6 hours. The reaction mixture is cooled, poured onto ice-water and extracted with tert-butyl methyl ether (2×). The combined organic phases are washed with water and brine, dried over sodium sulphate and concentrated by evaporation. The title compound is identified on the basis of the Rf value from the residue.

Provenance & Evidence