Triethylamine → HCID 66888311, compound

Participants

Reaction Steps

0.007 ml of propane-2-sulphonyl chloride is added to a solution of 0.026 g of tert-butyl {1-(2-amino -1-hydroxyethyl)-3-[3-(3-methoxypropyl)-1-methyl-1H-indol-5-ylmethyl]-4-methylpentyl}carbamate (Example 3Kb), and 0.007 ml of triethylamine in 1 ml of dichloromethane is added at 0° C. After 6 hours, the reaction mixture is concentrated by evaporation—the N-Boc intermediate is identified on the basis of the Rf value from the residue by means of flash chromatography (SiO2 60F). The N-Boc intermediate is dissolved in 0.82 ml of 4N HCl/dioxane—after 4 hours, the reaction mixture is concentrated by evaporation, and the residue is dissolved in 0.5 ml of tert-butanol, frozen in liquid nitrogen and lyophilized under high vacuum overnight. The title compound is identified on the basis of the Rf value from the residue.

Provenance & Evidence