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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 25243Generated: October 29, 2026

Ethyl (morpholin-4-ylcarbonothioyl)carbamate → {[1-(4-Cyano-1-propyl-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butylimino]-morpholin-4-yl-methyl}-carbamic acid ethyl ester

https://huagongshe.com/reaction/25243

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl (morpholin-4-ylcarbonothioyl)carbamateHCID 2824559—
Reactant2-Amino-4,4-dimethyl-pentanoic acid(4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride saltHCID 86585201—
Product{[1-(4-Cyano-1-propyl-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butylimino]-morpholin-4-yl-methyl}-carbamic acid ethyl esterHCID 22091417—

Reaction Steps

The title compound was prepared starting from (morpholine-4-carbothioyl)-carbamic acid ethyl ester and 2-amino-4,4-dimethyl-pentanoic acid (4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride salt according to the procedure from Example 5. MS, m/z 460=M+1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06858623B2
Source datasetuspto-grants-2005_02
ORD IDord-354640a82cc94fafa8de982153e07311
Source noteuspto-grants-2005_02