Water → HCID 67268225, compound

Participants

Reaction Conditions

Reaction Steps

To the crude product, (S)-toluene-4-sulfonic acid 2-cyclohexyl-pent-4-enyl ester, in DMSO (40 mL) was added NaCN, and the resulting mixture was heated at 90° C. for 1.5 h. The reaction mixture was cooled to room temperature and treated with H2O (20 mL). The reaction mixture was then extracted with diethylether (3×25 mL), dried (MgSO4) and concentrated in vacuo to yield a residue which was purified by Kugelrohr distillation (0.19 mm Hg, 80-90° C.) to yield (R)-3-cyclohexyl-hex-5-enenitrile.

Provenance & Evidence