Potassium Carbonate → HCID 11589308, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-chloropropane-1-sulfonic acid [4-(3-cyano-1-ethyl-6-methoxy-1H-indol-2-yl)-phenyl]amide, prepared above (3.65 g, 2.33 mmol) in DMF (100 mL) is treated with K2CO3 and heated at 70° C. for 2 h. After cooling to room temperature, the reaction mixture is diluted with H2O and extracted 3× with hot EtOAc. The hot organic layers are washed with warm H2O (3×) and saturated NaCl and dried and concentrated to a solid. Trituration (CH2Cl2/hexanes) gives 2.27 g (68%) of 2-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-1-ethyl-6-methoxy-1H-indole-3-carbonitrile as a light brown solid.

Provenance & Evidence