Trifluoroacetic acid → HCID 178482366, compound

Participants

Reaction Steps

To an orange solution of 1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)guanidine bis-t-butylcarbamate (1.1 g, 2.1 mmol) in 15 mL DCM under nitrogen at 0° C. was added TFA (3.1 ml, 41 mmol). The reaction was allowed to warm to ambient temperature and was allowed to stir overnight. The reaction was concentrated in vacuo to give 1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)guanidine bis-TFA salt as a brown oil, which was used without further purification. MS m/z=336 [M+H]+. Calc'd for C17H17N7O: 335.2.

Provenance & Evidence