反应详情

温度

80 °C

A slurry of 1-benzoyl-2-methyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)isothiourea (0.174 g, 0.37 mmol) and anhydrous hydrazine (0.35 ml, 11 mmol) in EtOH was sealed and heated to 80° C. After 16 h, a yellow precipitate formed. The reaction was cooled to ambient temperature, filtered, rinsing with 2×1 mL EtOH, and the solid was dried in vacuo to give N-methyl-4-(2-(4-(5-phenyl-4H-1,2,4-triazol-3-ylamino)phenoxy)pyridin-3-yl)pyrimidin-2-amine as a white solid. MS m/z=437 [M+H]+. Calc'd for C24H20N8O: 436.5.

1. customa yellow precipitate formed
2. temperatureThe reaction was cooled to ambient temperature
3. filtrationfiltered
4. washrinsing with 2×1 mL EtOH
5. customthe solid was dried in vacuo