Bromine → 4-Fluoro-2-(4'amino-3'-bromophenyl)benzothiazole

Participants

Reaction Steps

Bromine (0.8 mmol) was added to a solution of the 4-fluoro-2-(4′-aminophenyl) benzothiazole prepared as described in Example 3 (0.8 mmol) in dichloromethane (20 ml) at 10° C. The resulting solution was stirred for 10 min, then poured into water/ice (10 ml). The organic layer was removed and washed with 10% sodium thiosulfate (10 ml), water (10 ml) and evaporated. The product was purified by column chromatography (dichloromethane) to leave a white solid.

Provenance & Evidence