反应详情

温度

120 °C

A mixture of cesium carbonate (5.03 g, 15.4 mmol), 6-chloropyridin-3-ol (1.00 g, 7.72 mmol), and 4-(2-chloropyridin-3-yl)-2-(methylthio)pyrimidine (1.83 g, 7.72 mmol) was sealed and heated to 120° C. overnight. The reaction was cooled slightly and poured slowly into a rapidly stirring solution of 250 mL water. A tan precipitate resulted which was collected by filtration through a 0.45 micron filter. The solid was washed 3× with water, then dried in vacuo overnight to give 4-(2-(6-chloropyridin-3-yloxy)pyridin-3-yl)-2-(methylthio)pyrimidine as a tan solid. MS m/z=331 [M+H]+. Calc'd for C15H11ClN4OS: 330.8.

1. customwas sealed
2. temperatureThe reaction was cooled slightly
3. customA tan precipitate resulted which
4. filtrationwas collected by filtration through a 0.45 micron
5. filtrationfilter
6. washThe solid was washed 3× with water
7. customdried in vacuo overnight