HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline | HCID 396813 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole | HCID 9882781 | — |
Reaction Steps
Acetyl Chloride (0.09g, 1.55 mmol) was added to a solution of 5-fluoro2-(4′-amino-3′-methylphenyl)benzothiazole (0.2 g, 0.78 mmol) in chloroform (5 ml) containing triethylamine (86 mg, 0.85 mmol). The resulting solution was stirred for 30 min, then poured into water (20 ml). The organic layer was removed, dried (Na2SO4) and evaporated. Recrystallisation from ethanol gave a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858633B1 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-ae5991969bc04edba7258ddf1b0edf6e |
| Source note | uspto-grants-2005_02 |