HCID 66863946, compound → HCID 87183063, compound

Participants

Reaction Steps

By using optically active (R)-1-palmitoyl glycerol and optically active (S)-1-palmitoyl glycerol as the starting materials, and by carrying out Example 1 and Example 3, respectively, heptane solutions of (R)-1-palmitoyl-2-linoleoyl-3-tritylglycerol and (S)-1-palmitoyl-2-linoleoyl-3-tritylglycerol were obtained. Except for using the optically active compounds instead of racemic 1-palmitoyl-2-linoleoyl-3-trityl-glycerol, (S)-1-palmitoyl-2-linoleoyl-3-acetyl-glycerol (45.8 g) and (R)-1-palmitoyl-2-linoleoyl-3-acetyl-glycerol (45.8 g) were obtained in the same manner as described in Preparation method-3 (theoretical amounts: 63.5 g, yield: 72.1%). (R)-enantiomer: {1H NMR (400 MHz, CDCl3): δ 0.85-0.92 (m, 6H), 1.20-1.33 (m, 38H), 1.62 (m, 4H), 2.03 (m, 4H), 2.07 (s, 3H), 2.36 (m, 4H), 2.77 (m, 2H), 4.14-4.31 (m, 4H), 5.23-5.36 (m, 5H)}, (S)-enantiomer: {1H NMR (400 MHz, CDCl3): δ 0.85-0.92 (m, 6H), 1.21-1.33 (m, 38H), 1.63 (m, 4H), 2.02 (m, 4H), 2.07 (s, 3H), 2.37 (m, 4H), 2.78 (m, 2H), 4.12-4.28 (m, 4H), 5.21-5.35 (m, 5H)}.

Provenance & Evidence