反应详情

温度

100 °C

5-Fluoro-2-(4′-amino-3′-cyanophenyl)benzothiazole (1 g, 3.75 mmol) was dissolved in 80% sulfuric acid (50 ml) and heated at 100° C. for 2 hrs. After cooling, the reaction mixture was diluted with water (100 ml) and the pH adjusted to 7.5 using 50% sodium hydroxide. The product was extracted with ethyl acetate(3×50 ml), the extracts dried (Na2SO4) and evaporated to leave a yellow solid which was taken up in THF (20 ml) and added dropwise to a solution of LiAlH4 (0.7 g, 0.019 mol) in THF (15 ml). After stirring at 25° C. for 2 hrs, water (20 ml) was added and the product extracted with ethyl acetate (3×50 ml). The organic extracts were washed with brine (10 ml), dried (Na2SO4) and evaporated. The residue was purified by column chromatography (10% ethyl acetate/dichloromethane) to leave a yellow powder.

1. temperatureAfter cooling
2. extractionThe product was extracted with ethyl acetate(3×50 ml)
3. dry with materialthe extracts dried (Na2SO4)
4. customevaporated
5. customto leave a yellow solid which
6. extractionthe product extracted with ethyl acetate (3×50 ml)
7. washThe organic extracts were washed with brine (10 ml)
8. dry with materialdried (Na2SO4)
9. customevaporated
10. customThe residue was purified by column chromatography (10% ethyl acetate/dichloromethane)
11. customto leave a yellow powder