Ammonia → HCID 16220200, compound

HRID 252693Notes

Reaction equation

HRID 252693 reaction equation
[NH3:1].C[O:3][C:4](=O)[C@H:5]([CH2:7][CH2:8][S:9][C:10]([F:13])([F:12])[F:11])[NH2:6]>CO>[F:11][C:10]([F:13])([F:12])[S:9][CH2:8][CH2:7][C@@H:5]([C:4]([NH2:1])=[O:3])[NH2:6]

Participants

4

Reactant 2

HCID 222Ammonia3×HCID 101665086HCID 101665086, compound

Product 1

HCID 16220200HCID 16220200, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent5×

Conditions

Temperature
-15 °C

Procedure

5 ml of methanol was placed in an autoclave and cooled to −15° C., and ammonia gas was fed until methanol was saturated with the gas, to thereby prepare a solution of about 7 M ammonia in methanol. Trifluoromethionine methyl ester (50.4 mg, 0.199 mmol) was dissolved in methanol, and the solution was added to the solution of ammonia in methanol. The tube was sealed, and the mixture was stirred at 60° C. for 10 hours. The solvent was distilled off under reduced pressure, and recrystallization was performed with water, thereby 35.8 mg (89%) of trifluoromethionine amide(the general formula (II)) was obtained.

Workup

  1. customThe tube was sealed
  2. distillationThe solvent was distilled off under reduced pressure, and recrystallization

Sources & evidence

ORD record
ord-dc284a6645fa4274ada273767f48535c
Source dataset
uspto-grants-2011_01
Patent number
US07868206B2

Reaction notes

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