6-Chloronicotinoyl Chloride → HCID 86620387, compound

Participants

Reaction Steps

Using an analogous method to that described in Example 51, N-[5-(2-amino-4-methyl-1,3-thiazol-5-yl)-2-chloropyridin-3-yl]benzenesulfonamide was reacted with 6-chloronicotinoyl chloride. The reaction product was purified by preparative HPLC (Method A) to give the title product (retention time 8.5 minutes); 1H NMR Spectrum: (DMSO-d6+D2O) 8.58 (2H, dd); 8.44 (1H, d); 8.02 (3H, d); 7.86 (1H, t); 7.71 (2H, t); 7.51 (2H, d); 2.28 (3H, s); Mass Spectrum: M+H+ 520.

Provenance & Evidence