2-Furancarbonyl chloride → HCID 86620388, compound

Participants

Reaction Steps

Using an analogous method to that described in Example 51, N-[5-(2-amino-4-methyl-1,3-thiazol-5-yl)-2-chloropyridin-3-yl]benzenesulfonamide was reacted with 2-furoyl chloride. The reaction product was purified by preparative HPLC (Method A) to give the title product (retention time 8.0 minutes); 1H NMR Spectrum: (DMSOd6+D2O) 8.57 (1H, d); 8.27 (1H, d); 8.05 (2H, d); 7.83 (1H, t); 7.76 (1H, d); 7.69 (2H, t); 6.75 (1H, d); 6.55 (1H, dd); 2.25 (3H, s); Mass Spectrum: M+H+ 475.

Provenance & Evidence