Methoxyacetyl chloride → HCID 86620389, compound

Participants

Reaction Steps

Using an analogous method to that described in Example 51, N-[5-(2-amino-4-methyl-1,3-thiazol-5-yl)-2-chloropyridin-3-yl]benzenesulfonamide was reacted with 2-methoxyacetyl chloride. The reaction product was purified by preparative HPLC (Method A) to give the title product (retention time 7.0 minutes); 1H NMR Spectrum: (DMSOd6+D2O) 8.59 (1H, d); 8.14 (1H, d); 8.03 (2H, d); 7.83 (1H, t); 7.70 (2H, t); 4.01 (1H, d); 3.72 (1H, d); 3.18 (3H, s); 2.27 (3H, s); Mass Spectrum: M+H+ 453.

Provenance & Evidence