Trimethylsilyl isocyanate → HCID 86620397, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of trimethylsilyl isocyanate (0.032 mL), N-[5-(2-amino-4-methyl-1,3-thiazol-5-yl)-2-chloropyridin-3-yl]-2,4-dimethylthiazole-5-sulfonamide (46 mg) and DME (1 mL) was placed in a sealed glass reaction vessel and heated to 115° C. in a microwave reactor for 18 hours. The resultant mixture was evaporated and the residue was purified by preparative HPLC on reversed-phase silica using a solvent gradient of 10% to 100% acetonitrile in water (containing 1% acetic acid) as eluent. The material so obtained was triturated under diethyl ether. There was thus obtained the title compound as a solid (16 mg); 1H NMR Spectrum: (DMSOd6) 2.28 (s, 3H), 2.34 (s, 3H), 2.62 (s, 3H), 6.47 (br s, 2H), 7.71 (s, 1H), 8.34 (br s, 1H), 10.55 (s, 1H), 10:85 (br s, 1H); Mass Spectrum: M+H+ 459.

Provenance & Evidence