Benzenesulfonyl chloride → HCID 86620407, compound

Participants

Reaction Steps

Benzenesulfonyl chloride (0.062 mL) was added to a stirred mixture of N-[5-(5-aminopyridin-2-yl)-4-methyl-1,3-thiazol-2-yl]acetamide (100 mg) and pyridine (1 mL) and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was evaporated and the residue was triturated under methanol. The resultant precipitate was filtered off, washed in turn with methanol and diethyl ether and dried. There was thus obtained the title compound (85 mg); 1H NMR Spectrum: (DMSOd6) 2.13 (s, 3H), 2.47 (s, 3H), 7.55-7.65 (m, 5H), 7.80 (m, 2H), 8.26 (m, 1H), 10.58 (s, 1H), 12.05 (s, 1H); Mass Spectrum: M+H+ 389.

Provenance & Evidence