Cesium fluoride → N-[4-Methyl-5-(6-phenylsulfonylaminopyrazin-2-yl)-1,3-thiazol-2-yl]acetamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetamido-4-methylthiazole (891 mg), N-(6-chloropyrazin-2-yl)benzenesulfonamide (1.4 g), palladium acetate (94 mg), caesium fluoride (2.35 g), tri-tert-butylphosphine (0.34M in hexane, 2.4 mL) and DMSO (45 mL) was purged with nitrogen. The resultant mixture was stirred and heated to 160° C. for 3.5 hours. The bulk of the DMSO was evaporated and water (50 mL) was added. The resultant solid was filtered off, washed with water and dried under vacuum. A 19:1 mixture of dichloromethane and methanol was added and the mixture was filtered. The filtrate was evaporated and the residue was purified by column chromatography on silica using a solvent gradient of 3% to 5% methanol in dichloromethane as eluent. There was thus obtained the title compound as a solid (95 mg); 1H NMR Spectrum: (DMSOd6) 2.20 (s, 3H), 2.49 (s, 3H), 7.60-7.70 (m, 3H), 8.06 (m, 2H), 8.11 (s, 1H), 8.47 (s, 1H), 11.68 (s, 1H), 12.27 (s, 1H); Mass Spectrum: M+H+ 390.

Provenance & Evidence