Methanol → HCID 86244451, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (1.5 mL) was added to a stirred mixture of N-[5-(6-chloro-5-tritylaminopyridazin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide (300 mg), methanol (0.5 mL) and dichloromethane (4 mL) that had been cooled to 0° C. The resultant mixture was heated to 55° C. for 5 hours. The mixture was evaporated and the residue was basified to pH8 by the addition of a saturated aqueous sodium bicarbonate solution. The resultant solid was isolated and washed with diethyl ether. The solid was dissolved in dichloromethane and a 7M methanolic ammonia solution was added. The mixture was evaporated to give N-[5-(5-amino-6-chloropyridazin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide as a solid; Mass Spectrum: M+H+ 282.

Provenance & Evidence