Benzenesulfonamide → HCID 86620417, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[5-(6-chloropyridazin-4-yl)-4-methyl-1,3-thiazol-2-yl]acetamide (55 mg), benzenesulphonamide (49 mg), caesium carbonate (101 mg), cuprous iodide (30 mg) and DMA (1.5 mL) was heated in a microwave reactor to 200° C. under an argon atmosphere for 3 hours. The resultant mixture was evaporated and the residue was purified by preparative HPLC on reversed phase silica using a solvent gradient of 10% to 100% acetonitrile in water (containing 1% acetic acid) as eluent. The material so obtained was triturated under diethyl ether. There was thus obtained the title compound as a solid (7.3 mg); 1H NMR Spectrum: (DMSOd6+CD3CO2D) 2.20 (s, 3H), 2.43 (s, 3H), 7.51-7.64 (m, 3H), 7.75 (s, 1H), 7.89 (d, 2H), 8.51 (s, 1H); Mass Spectrum: M+H+ 390.

Provenance & Evidence