Ethanol → HCID 67262644, compound

Participants

Reaction Steps

To a 250 mL flask were added 16 (2.0 g, 4.17 mmol), ethanol (60 mL) and conc. sulfuric acid (0.2 mL). The mixture was heated at reflux for 2 h and then was cooled to rt. The ethanol was removed in vacuo and the residue was partitioned between water (40 mL) and DCM (80 mL). The organic layer was washed with 1 M HCl (40 mL), water (40 mL) and then with a solution of sodium iodide. It was dried (MgSO4) and evaporated in vacuo to afford 17 as a brown solid (1.74 g, 82%).

Provenance & Evidence