Methyl formate → HCID 23440560, compound

HRID 252799Notes

Reaction equation

HRID 252799 reaction equation
[CH3:1][C:2]1[C:10]([CH3:12])([CH3:11])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:13][NH2:14])[CH:8]=2)[N:3]=1.[CH:15](OC)=[O:16]>>[CH3:1][C:2]1[C:10]([CH3:11])([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:13][NH:14][CH:15]=[O:16])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 7865Methyl formateHCID 23440561HCID 23440561, compound

Product 1

HCID 23440560HCID 23440560, compoundYield 95%

Procedure

Aminomethylindole 36 (1.29 g, 6.86 mmol) was dissolved in methyl formate (40 mL) and the mixture was heated at reflux for 2 days. The volatile components were evaporated in vacuo to afford the protected amine 37 as a pale yellow oil (1.40 g, 95%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 2 days
  3. customThe volatile components were evaporated in vacuo

Sources & evidence

ORD record
ord-841c69efebb646d395e983ba30eb8adc
Source dataset
uspto-grants-2011_01
Patent number
US07868157B2

Reaction notes

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