HCID 178521762, compound → HCID 178507407, compound

Participants

Reaction Steps

The nitro compound 171 (20 mg, 0.05 mmol) was hydrogenated (1 atm) in the presence of 10% palladium on charcoal (catalytic amount) in methanol (1 mL) at room temperature for 2-3 hrs. The reaction mixture was filtered through a pad of Celite®, the filtrate was evaporated to give the crude product which was suspended in dichloromethane and stirred overnight at room temperature, then filtered to provide the title compound 172 (6.3 mg, 27% yield). 1H NMR: (DMSO) δ (ppm): 400 MHz, (DMSO) d (ppm): 9.71 (s, 1H), 8.07 (d, J=8.2 Hz, 2H), 8.00 (d, J=8.2 Hz, 2H), 7.48 (s, 1H), 7.34 (d, J=5.1 Hz, 1H), 7.28 (dd, J=8.2, 2.0 Hz, 1H), 7.24 (d, J=3.5 Hz, 1H), 7.03 (t, J=3.7 Hz, 1H), 6.79 (d, J=8.4 Hz, 1H), 5.17 (s, 2H). MS: 362.09 (calc), 363.1 (obs).

Provenance & Evidence