HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 70336350, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate | HCID 57717474 | — |
| Reactant | HCID 66894634 | HCID 66894634 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 70336350 | HCID 70336350 | 47% |
Reaction Steps
A solution of acid 339 (113 mg, 0.34 mmol) amine 178 (100 mg, 0.34 mmol) and BOP (152 mg, 0.34 mmol) in pyridine (2 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and purified by flash chromatography using gradient eluent 50%-75% EtOAc in hexanes to afford the title compound 340 (96 mg, 47% yield). MS: calc: 600.1; found: 601.3 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868205B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-7e70ce4d05154dc5bf5fb56c79382a95 |
| Source note | uspto-grants-2011_01 |