Fumaric Acid → HCID 131720570, compound

HRID 2529Notes

Reaction equation

[CH:1]([NH:3][C:4]1[CH:35]=[CH:34][C:7]([C:8]([N:10]([CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:33])[C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:9])=[CH:6][CH:5]=1)=[O:2].[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40]>>[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40].[CH:1]([NH:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([N:10]([CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][CH:22]([C:25](=[O:33])[C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)[CH2:23][CH2:24]2)[C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:9])=[CH:34][CH:35]=1)=[O:2].[CH:1]([NH:3][C:4]1[CH:35]=[CH:34][C:7]([C:8]([N:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:33])[C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)=[O:9])=[CH:6][CH:5]=1)=[O:2]

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 19689891HCID 19689891, compound

Product 1

HCID 131720570HCID 131720570, compoundYield 52.1%

Procedure

Using 4-formylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-pyridyl)benzamide (208.8 mg, 0.44 mmol) and fumaric acid (25.8 mg, 0.22 mmol), the procedure of Inventive Example 271 was repeated to obtain 122.2 mg (52.1%) of the title compound in a colorless powder form.

Sources & evidence

ORD record: ord-1d509de57fab4ad7907e706bebccd055
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728835

Reaction notes

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