Methanol → HCID 66862662, compound

Participants

Reaction Steps

A suspension of 270 mg (1.05 mmol) of 1-Boc-3-(thiazol-2-ylamino)azetidine in MeCN (5 ml) was combined with 68 mg (1.2 mmol, 60% strength in mineral oil) of sodium hydride and stirred for 30 min at RT. 151 μl (1.73 mmol) of iodomethane were then added and stirring continued for a further 16 h at RT. After addition of MeOH (200 μl), evaporation under a vacuum was carried out. 166 mg (0.62 mmol, 59%) of 1-Boc-3-(methyl(thiazol-2-yl)amino)azetidine were obtained by CC (hexane/EA 3:2) with the residue.

Provenance & Evidence