Ethyl 4,7-dichloro-6-fluoroquinoline-3-carboxylate → HCID 178515201, compound

HRID 252964Notes

Reaction equation

HRID 252964 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:12](=[O:21])[N:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:14]=[C:5]3[C:4]=2[CH:3]=1.C(OC(C1C=NC2C(C=1[Cl:37])=CC(F)=C(Cl)C=2)=O)C>>[Cl:37][C:11]1[C:2]([F:1])=[CH:3][C:4]2[C:5]3[C:6]([C:12](=[O:21])[N:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:14]=3)=[CH:7][NH:8][C:9]=2[CH:10]=1

Participants

3

Reactant 2

HCID 2779525Ethyl 4,7-dichloro-6-fluoroquinoline-3-carboxylateHCID 178515196HCID 178515196, compound

Product 1

HCID 178515201HCID 178515201, compound

Procedure

The title compound was prepared following procedure for 23a using ethyl-4,7-dichloro-6-fluoro-quinoline-3-carboxylate. 1H-NMR (DMSO-d6) δ (ppm): 7.20 (1H, t, J=7.41 Hz), 7.48 (3H, m), 8.19 (2H, m), 8.43 (1H, dd, J=8.79, 2.46 Hz), 8.54 (1H, d, J=2.20 Hz), 8.92 (1H, s). m/z 314.7 (MH+).

Sources & evidence

ORD record
ord-f200dee5bb834c6ab20daa3ab35794e4
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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