N,N-Dimethylpiperidin-4-amine → HCID 178482915, compound

HRID 252968Notes

Reaction equation

HRID 252968 reaction equation
[F:1][C:2]1[C:11]([N:12]2[CH2:17]CN[CH2:14][CH2:13]2)=[CH:10][C:9]2[NH:8][CH:7]=[C:6]3[C:18](=[O:27])[N:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[N:20]=[C:5]3[C:4]=2[CH:3]=1.FC1C(F)=CC2C3C(C(=O)N(C4C=CC=CC=4)N=3)=CNC=2C=1.[CH3:50][N:51]([CH3:58])[CH:52]1CCNC[CH2:53]1>>[CH3:50][N:51]([CH3:58])[CH:52]1[CH2:14][CH2:13][N:12]([C:11]2[C:2]([F:1])=[CH:3][C:4]3[C:5]4[C:6]([C:18](=[O:27])[N:19]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=5)[N:20]=4)=[CH:7][NH:8][C:9]=3[CH:10]=2)[CH2:17][CH2:53]1

Participants

4

Reactant 3

HCID 417391N,N-Dimethylpiperidin-4-amineHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178482915HCID 178482915, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and 4-dimethylaminopiperidine. 1H-NMR (DMSO-d6) δ (ppm): 1.56 (2H, brm), 1.89 (2H, brm), 2.22 (6H, s), 2.74 (2H, brm), 3.13 (1H, brm), 3.52 (2H, brm), 7.10 (1H, m), 7.22 (1H, d, J=7.96 Hz), 7.40 (2H, t, J=7.42 Hz), 7.76 (2H, d, J=2.91 Hz), 8.20 (2H, m), 8.64 (1H, s). m/z 406.4 (MH+).

Sources & evidence

ORD record
ord-414f371b504242f99a0fb304483c34fa
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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