1-Methylhomopiperazine → HCID 178480421, compound

HRID 252971Notes

Reaction equation

HRID 252971 reaction equation
F[C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=CC2NC=C3C(=O)N(C4C=CC=CC=4)N=C3C=2C=1.F[C:29]1[C:30]([F:49])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:48])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.CN1CCCNCC1>>[F:49][C:30]1[C:29]([N:15]2[CH2:14][CH2:2][CH2:11][N:12]([CH3:13])[CH2:17][CH2:16]2)=[CH:38][C:37]2[NH:36][CH:35]=[C:34]3[C:39](=[O:48])[N:40]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[N:41]=[C:33]3[C:32]=2[CH:31]=1

Participants

4

Reactant 3

HCID 2283491-MethylhomopiperazineHCID 178515218HCID 178515218, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178480421HCID 178480421, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27a and 1-methylperhydro[1,4]-diazepine. 1H-NMR (DMSO-d6) δ (ppm): 1.98 (2H, brm), 2.27 (3H, s), 2.68 (4H, brm), 3.24 (4H, brm), 7.15 (2H, m), 7.40 (2H, m), 7.76 (1H, d, J=2.91 Hz), 8.20 (2H, m), 8.64 (1H, s). m/z 392.2 (MH+).

Sources & evidence

ORD record
ord-afe2e552bc5d472b80e0ae3b73b23a51
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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