Morpholine → HCID 178515229, compound

HRID 252976Notes

Reaction equation

HRID 252976 reaction equation
FC1C(N2CCNCC2)=CC2NC=C3C(=O)N(C4C=CC=CC=4)N=C3C=2C=1.F[C:29]1[C:30]([F:48])=[CH:31][C:32]2[C:33]3[C:34]([C:39](=[O:47])[N:40]([C:42]4[CH:46]=[CH:45][S:44][CH:43]=4)[N:41]=3)=[CH:35][NH:36][C:37]=2[CH:38]=1.[NH:49]1[CH2:54][CH2:53][O:52][CH2:51][CH2:50]1>>[F:48][C:30]1[C:29]([N:49]2[CH2:54][CH2:53][O:52][CH2:51][CH2:50]2)=[CH:38][C:37]2[NH:36][CH:35]=[C:34]3[C:39](=[O:47])[N:40]([C:42]4[CH:46]=[CH:45][S:44][CH:43]=4)[N:41]=[C:33]3[C:32]=2[CH:31]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 178515220HCID 178515220, compoundHCID 178515226HCID 178515226, compound

Product 1

HCID 178515229HCID 178515229, compound

Procedure

The title compound was prepared following the procedure described in the synthesis of 28a using 27d and morpholine. 1H-NMR (DMSO-d6) δ (ppm): 3.11 (4H, brm), 3.79 (4H, brm), 7.21 (1H, m), 7.58 (1H, m), 7.79 (3H, m), 8.67 (1H, m). m/z 371.2

Sources & evidence

ORD record
ord-da61dc4972074a51a1d49f59bdf009bd
Source dataset
uspto-grants-2011_01
Patent number
US07872002B2

Reaction notes

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