HCID 66841025, compound → HCID 58613213, compound

Participants

Reaction Steps

Compound 91, N-[2-(2-benzyloxy-ethyl)-6-morpholin-4-yl-pyrimidin-4-yl]-N′-(3-methyl-benzylidene)-hydrazine (109 mg., 0.25 mmol) was dissolved in ethanol (20 mL) and to the solution was added 10% palladium on carbon (200 mg.), three drops of glacial acetic acid, and the reaction was stirred at room temperature under 1 atmosphere of hydrogen for 4 hours. The reaction was passed through celite, evaporated and purified by column chromatography to give Compound 92, N-[2-(2-benzyloxy-ethyl)-6-morpholin-4-yl-pyrimidin-4-yl]-N′-(3-methyl-benzyl)-hydrazine (106 mg., 24 mmol).

Provenance & Evidence