Tetrahydrofuran → N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethyl)-pyrimidin-4-yl]-hydrazine

Participants

Reaction Conditions

Reaction Steps

Compound 95, methanesulfonic acid 2-{4-[N′-(3-methyl-benzylidene)-hydrazino]-6-morpholin-4-yl-pyrimidin-2-yl}-ethyl ester (104 mg., 0.25 mmol) was dissolved in tetrahydrofuran (4 mL). To the reaction mixture was added morpholine (43 mg., 0.5 mmol) and the vessel was sealed and heated at 80° C. for sixteen hours. The solvent was removed under reduced pressure and the crude oil was purified by column chromatography to give Compound 94, N-(3-methyl-benzylidene)-N′-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethyl)-pyrimidin-4-yl]-hydrazine (52 mg., 0.13 mmol).

Provenance & Evidence