反应详情

温度

-78 °C

2-Methyl-4,6-dichloropyridine (256 mmol) is dissolved in dichloromethane (200 mL) and chilled to −78° C. in an inert atmosphere. Morpholine (550 mol) dissolved in dichloromethane (100 mL) is added slowly. The reaction is allowed to warm to room temperature while stirring overnight. The organic layer is washed with saturated ammonium chloride (2×100 mL), dried with sodium sulfate, and evaporated to give 2-methyl-4-chloro-6-morpholino-pyridine.

1. additionis added slowly
2. temperatureto warm to room temperature
3. washThe organic layer is washed with saturated ammonium chloride (2×100 mL)
4. dry with materialdried with sodium sulfate
5. customevaporated