反应详情

3-(4-Chloro-6-morpholin-4-yl-pyrid-2-yl)-propan-1-ol (19.4 mmol) is dissolved in dioxane (30 mL). To the reaction mixture is added anhydrous hydrazine (10 mL, 300 mmol). The reaction is then heated at reflux for five hours. The solvent is removed under reduced pressure, and the crude solid is dissolved in a mixture of dichloromethane (800 mL) and 10% potassium carbonate (40 mL). The organic layer is isolated, dried with sodium sulfate, and evaporated to yield crude 3-(4-hydrazino-6-morpholin-4-yl-pyrid-2-yl)-propan-1-ol (4.3 g., 17 mmol).

1. temperatureThe reaction is then heated
2. temperatureat reflux for five hours
3. customThe solvent is removed under reduced pressure
4. dissolutionthe crude solid is dissolved in a mixture of dichloromethane (800 mL) and 10% potassium carbonate (40 mL)
5. customThe organic layer is isolated
6. dry with materialdried with sodium sulfate
7. customevaporated