Monomethylamine methanol → HCID 66862315, compound

HRID 253004Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15]I)=[O:9])=[CH:4][CH:3]=1.CO.[CH3:19][NH2:20]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][NH:20][CH3:19])=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 57454252Monomethylamine methanol

HCID 66862085HCID 66862085, compound

Product 1

HCID 66862315HCID 66862315, compoundYield 59%

Procedure

The title compound (80 mg, 0.20 mmol) produced in step (ix) of Reference Example 8 was dissolved in 1 ml of a 40% methylamine methanol solution, and the mixture was stirred at room temperature for 44 hr. The reaction solution was concentrated under the reduced pressure, and the residue was purified by preparative thin layer chromatography (chloroform:methanol:28% aqueous ammonia=5:1:0.1) to give 36 mg (yield 59%) of the title compound.

Workup

concentrationThe reaction solution was concentrated under the reduced pressure
customthe residue was purified by preparative thin layer chromatography (chloroform:methanol:28% aqueous ammonia=5:1:0.1)

Sources & evidence

ORD record: ord-785baafcc2304b7990f8e4c1484c17e6
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07871982B2

Reaction notes

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