反应详情

Triethylamine (0.94 ml, 6.74 mmol) was added to a solution of 400 mg (4.49 mmol) of (S)-2-aminobutan-1-ol in tetrahydrofuran (5 ml), and the mixture was stirred at room temperature for 10 min. 2-Nitrobenzenesulfonyl chloride (995.1 mg, 4.49 mmol) was added to the solution, and the mixture was stirred at room temperature for 15 min. A saturated aqueous sodium hydrogencarbonate solution was added thereto to stop the reaction, and the reaction solution was then extracted with ethyl acetate, was dried over anhydrous sodium sulfate, and was filtered. The filtrate was concentrated under the reduced pressure, and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1) to give 1.22 g (yield 99%) of the title compound.

1. stirringthe mixture was stirred at room temperature for 15 min
2. customthe reaction
3. extractionthe reaction solution was then extracted with ethyl acetate
4. dry with materialwas dried over anhydrous sodium sulfate
5. filtrationwas filtered
6. concentrationThe filtrate was concentrated under the reduced pressure
7. customthe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1)