Sodium Acetate → HCID 135871516, compound

HRID 253020Notes

Reaction equation

HRID 253020 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10](=[O:17])[C:11]3[S:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:5]=[CH:6][CH:7]=1.[C:18]([O-])(=[O:20])[CH3:19].[Na+]>C(OC(=O)C)(=O)C>[O:17]=[C:10]1[NH:9][C:8]([C:4]2[CH:3]=[C:2]([O:1][C:18](=[O:20])[CH3:19])[CH:7]=[CH:6][CH:5]=2)=[N:13][C:12]2[CH:14]=[CH:15][S:16][C:11]1=2

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 135863375HCID 135863375, compound

Product 1

HCID 135871516HCID 135871516, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of 2-(3-hydroxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one (28.58 g, 0.12 mol) and sodium acetate (1.1 eq., 0.13 mol, 10.56 g) in acetic anhydride (280 mL) was heated under reflux for 1.5 hours. The mixture was then cooled in ice-water and the grey solid collected by filtration, washed with water and dried to yield compound 4 (27.69 g, 82%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. filtrationthe grey solid collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-49fd6316691c47778d56170c52acf7d8
Source dataset
uspto-grants-2011_01
Patent number
US07872003B2

Reaction notes

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