反应详情

A mixture of 2-(3-hydroxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one (28.58 g, 0.12 mol) and sodium acetate (1.1 eq., 0.13 mol, 10.56 g) in acetic anhydride (280 mL) was heated under reflux for 1.5 hours. The mixture was then cooled in ice-water and the grey solid collected by filtration, washed with water and dried to yield compound 4 (27.69 g, 82%).

1. temperaturewas heated
2. temperatureunder reflux for 1.5 hours
3. filtrationthe grey solid collected by filtration
4. washwashed with water
5. customdried