Tetrabutylammonium Fluoride → HCID 66857745, compound

Participants

Reaction Steps

(1-{2-[3-(Tert-butyl-dimethyl-silanyloxy)-phenyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl}-piperidin-4-yl)-carbamic acid tert-butyl ester (250 mg, 0.39 mmol) was dissolved in THF (4 mL), to this was added TBAF (1.4 eq., 0.55 mL). After 30 min. the reaction mixture was quenched with silica, evaporated in vacuo and purified by chromatography to give {1-[2-(3-hydroxy-phenyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester as a white solid (179 mg, 88%).

Provenance & Evidence