関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid | HCID 125216 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Amino-5-Chloro-alpha-(Methoxyimino)-4-Thiazoleacetic Acid | HCID 54009366 | — |
反応手順
To 500 mL of acetic acid were added 40.0 g (0.20 mol) of 2-amino-α-(methoxyimino)-4-thiazoleacetic acid (Aldrich Chemical Company, Milwaukee, Wis.) and 27.9 g (0.21 mol) N-chlorosuccinimide. The mixture was heated in a 70° C. bath. The solids dissolved within 30 minutes, and after 45 minutes the reaction was complete by MS. The dark solution was allowed to cool to room temperature and concentrated under vacuum to give a dark solid, which was used without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07871997B2 |
|---|
| 出典データセット | uspto-grants-2011_01 |
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| ORD ID | ord-c9e1f5ca1aa447e3a92137d13921a8f8 |
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| 出典メモ | uspto-grants-2011_01 |
|---|
